RNA Details
Disease Name
diabetic cardiomyopathy
Tissue
heart
RNA Symbol
mir-34a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
qRT-PCR; Cell Counting Kit-8 assays;dual-luciferase reporter assay
Target
Pin-1
Pathway
NA
PubMed ID
Title
miR-34a attenuates myocardial fibrosis in diabetic cardiomyopathy mice via targeting Pin-1
Year
2021
Function
"MiR-34a can attenuate myocardial fibrosis in DCM by reducing Type I collagen production, cell viability, and migration and increasing the apoptosis of CFs by targeting Pin-1 signaling."